Endocrine Abstracts

Primary hyperparathyroidism is currently recognized with increasing frequency by routine calcium measurement in biochemical examinations. Primary hyperparathyroidism may be due to a parathyroid adenoma, parathyroid hyperplasia and, rarely, parathyroid carcinoma. Cinacalcet is used in the medical management of primary hyperparathyroidism.The aim was to assess the role of cinacalcet in the treatment of primary hyperparathyroidism.Pat...

Objective: The clinical phenotype of PCOS includes reproductive and hormonal aberrations. Visceral adiposity index (VAI) is an indicator which could connect hyperandrogenism and anovulation. The objective was to evaluate the relationship between VAI, menstrual disorders and hormonal, biochemical and ultrasound parameters in women with PCOS.Patients: 180 women with PCOS diagnosed with Rotterdam criteria.Measurements: We correlated V...

Objective: To report the unusual presentation of a thyrotropinoma in a patient with: i) accelerated bone turnover, evident as osteopenia and increased serum alkaline phosphatase level, and ii) a pericardial effusion, years before diagnosis, that resolved completely following surgery and somatostatin analogue treatment.Case report: A 38-year-old man had been treated for years for presumed hypothyroidism with thyroxine supplementation based on elevated TSH...

It is well established that overt maternal hypothyroidism and subclinical hypothyroidism may be associated with an adverse outcomes for both the mother and offspring. Therefore, maternal hypothyroidism should be early diagnosed and treated.Aim: The present study was designed in order to investigate thyroid function in the three trimesters of pregnancy, according to the recently updated guidelines.Materials and methods: One hundred ...

Objectives: Patients with thyroid dysfunction due to AITD have been found to have increased oxidative stress. Possible associations of oxidative stress with thyroid hormone (TH) and thyroid autoantibodies (ThAb) levels in euthyroid patients with autoimmune thyroiditis have not been adequately studied. We examined possible associations of oxidative stress markers with TH levels and with the presence of ThAb in euthyroid women with Hashimoto’s thyroiditis (with or without T...

Aim: Thyroid cancer comprises the most common endocrine malignancy and a variety of studies have examined the incidence of microcarcinomas in benign thyroid disorders. Objective of the present retrospective study was the assessment of the possible influence of age and gender parameters in the presence of thyroid microcarcinoma in a patient cohort with non-autonomous thyroid disorders and without cytological establishment of cancer who underwent total thyroidectomy.<p class...

Introduction: The clinical profile of patients with primary hyperparathyroidism has changed significantly in the last decades considering the fact that most cases are asymptomatic. This could be attributed to early diagnosis due to routinely serum calcium measurement. Only 5–27% of patients present with symptoms or signs related to osteoporosis, nephrolithiasis and hypercalcaemia. However, in patients with asymptomatic primary hyperparathyroidism (APHP) data concerning t...

Introduction: The molecular pathogenesis of pancreatic neuroendocrineneoplasms (PNEN) is increasingly yet incompletely understood. PNEN typically occur sporadically or may occur within the context of hereditary tumor predisposition syndromes. PNEN can also be associated with endocrinopathy of hormonal hypersecretion. We present a young male with a multi-hormonal neuroendocrine neoplasm of pancreas.Case presentation: A 24-year-old male, non-smok...

Introduction: Current testosterone replacement therapies have limited acceptability: gels can be messy and risk inadvertent dosing of others; injections are painful; and oral testosterone undecanoate (TU) delivers variable testosterone levels, requires concurrent ingestion of a fatty meal and may produce supraphysiological dihydrotestosterone (DHT) levels1. We present the first human trial of an oral native testosterone preparation formulated to deliver testosterone...

Background: Childhood and adolescence are critical periods for the establishment of lifelong bone health. While most studies focus on vitamin-D regardless of PTH levels, Normocalcemic Primary Hyperparathyroidism (NPHPT) has been recognized more than 15 years ago as a variant of primary hyperparathyroidism (PHPT), characterized by persistently elevated PTH with normal albumin-adjusted total and ionized calcium, in the absence of secondary causes of hyperparathyroidism. PPHPT is...